Joint Pain Forum – News you can use!
variant associated with susceptibility to osteoarthritis
Nature Genetics on Apr 02 2007 11:51:04
A variant in a gene called GDF5 is
associated with the risk of developing osteoarthritis, a study
published online this week in Nature Genetics suggests. Osteoarthritis
is the most common form of arthritis, affecting more than 20 million
people in the United States.
is caused by the breakdown and loss of the cartilage in one or more
joints during ageing, leading to swelling, pain, and limited mobility.
Shiro Ikegawa and colleagues analyzed variation across the GDF5 gene
and found that one particular variant was significantly more frequent
in two independent populations of Japanese individuals with
osteoarthritis of the hip compared to disease-free individuals.
same variant was also found to be significantly more frequent in both
Japanese and Chinese individuals suffering from osteoarthritis of the
knee. Depending on the study, the variant conferred 30%-80% additional
risk of developing the disease. The authors showed that this variant
probably reduces the amount of GDF5 produced. As GDF5 is a protein that
is secreted by cells and is known to be involved in cartilage
development, lower levels of GDF5 may affect the maintenance of
cartilage in joints
Map | CONTACT