Joint Pain Forum – News you can use!
and Aspirin Can be a Deadly Combo
April 27, 2007
painkiller ibuprofen could boost the likelihood of heart problems in
high-risk patients with osteoarthritis.
Researchers examined the cardiovascular
health of more than 18,000 osteoarthritis patients over the age of 50.
The patients were taking part in the
Therapeutic Arthritis Research and Gastrointestinal Event Trial
(TARGET), and were either taking a high dose of lumiracoxib, a COX-2
inhibitor, ibuprofen, or naproxen.
whose risk of cardiovascular disease was deemed low during the study
remained that regardless of their drug regimen. But 10 percent were
considered to be at high risk of a heart attack or stroke; some of
these patients were taking low-dose aspirin for this problem.
When these high-risk patients were taking
both aspirin and ibuprofen, they were nine times as likely to have
heart attacks and strokes over the course of a year as those on
lumiracoxib. Previous studies have suggested that ibuprofen interferes
with the effects of aspirin.
high-risk patients not taking aspirin, the rate of heart attacks or
strokes was higher than for those on COX -2 inhibitors and ibuprofen
than it was for those on naproxen.
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