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Linked to Gene Mutation
Unusual DNA Pattern Seen in Cartilage Gene
of Osteoarthritis Patients
By M.Hitti; WebMD Medical News
by Louise Chang, MD
Variations in a cartilage gene may
increase the odds of developing osteoarthritis, a Japanese study shows.
osteoarthritis, the most common type of arthritis, the cartilage that
covers and cushions joints wears down. The gene in question helps
develop cartilage, say the researchers.
included Shiro Ikegawa, MD, PhD, head of the Laboratory for Bone and
Joint Diseases at Tokyo's RIKEN, a science and technology research
Ikegawa and colleagues screened the GDF5 gene in 24 people with hip
osteoarthritis, several DNA variations in the GDF5 gene stood out.
findings, the researchers screened the GDF5 gene in 239 Japanese hip
osteoarthritis patients, 718 Japanese knee osteoarthritis patients, and
more than 1,100 Japanese people without osteoarthritis.
in the GDF5 gene were more common in the osteoarthritis patients than
in the people without osteoarthritis.
was true when the researchers looked at a group of 313 Chinese patients
with knee osteoarthritis and 485 Chinese people without osteoarthritis.
findings don't mean GDF5 is the only gene that affects osteoarthritis.
study "will open a new window" in osteoarthritis research and may
eventually lead to new treatments, the researchers write in Nature
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