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Glucosamine and Chondroitin Are More Effective Than Pain Relievers

The GAIT Study Reveals the Latest Major Glucosamine Clinical Trial Results...

Two long-anticipated major clinical studies - the GAIT Study and the GUIDE Trial - have recently found that Glucosamine and Chondroitin Sulfate, work even better than common pain killers.

With the ever increasing interest on how to overcome the challenges of living with osteoarthritis, particularly with two major prescription drugs (Vioxx and Bextra) being removed from the market, along with concerns about long term NSAID usage... these findings have never been more relevant and important to arthritis sufferers and their care givers.


Subject matter Quick Links for this page…

Summary of the scientific findings:

1) GAIT Study
2) GUIDE Trial
3) Additional Commentary

GAIT Study (Glucosamine/Chondroitin Arthritis Intervention Trial) - Glucosamine Effectiveness trial

• The GAIT study cost more that $12.5 million to conduct
• Included researchers and contributions from 13 American Universities
• Five year study
• Results summary:
After five years of recruiting, testing and analyzing, this trial reports, “Combination glucosamine and chondroitin sulfate is effective in treating moderate to severe knee pain due to osteoarthritis.”

Additional details:

Under the direction of the NIH (National Institutes of Health), one of the world’s foremost medical research centers, 13 highly prestigious research universities in the United States performed this randomized, double-blind, placebo controlled, parallel assignment, efficacy study on over 1,500 osteoarthritis sufferers.

For 24 weeks, each participant was given a daily dose of either:

• glucosamine hydrochloride
• chondroitin sulphate
• some combination of both
• 200 mg of the prescription painkiller celecoxib, a cox-2 drug (Celebrex®)or a placebo
All patients' pain levels were evaluated at the beginning of the study and again at the end of the four weeks. The Glucosamine and Chondroitin combination was found to significantly reduce pain compared to placebo and Celebrex® (celecoxib), using the WOMAC Pain Index (Western Ontario and McMaster Osteoarthritis Index).

This study marks the very first time that a well designed study of this scale has been done on a supplement and the results were shocking to many but exactly what many Glucosamine users have know for years.

This study was conducted by the National Institutes of Health at thirteen distinguished colleges, using taxpayer’s – not a manufacturer’s - dollars. This guaranteed and unbiased and reliable result.

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GUIDE Trial - The Glucosamine Unum-in-Die (Once a Day) Efficacy (GUIDE) Trial

At about the same time the University based GAIT study results were released in the United States, an independent Hospital based European study - known as the GUIDE Trial - released its results. They too, showed the extraordinary benefits of glucosamine.


• After 24 weeks of monitoring osteoarthritis sufferers, the study clearly showed superior effectiveness of the glucosamine dietary supplement (even at half the dosage of the drug) on many levels of discomfort and mobility.
• The study confirmed that glucosamine was shown to be more effective than the most commonly used pain reliever, acetaminophen.
• “Glucosamine sulfate…might be the preferred symptomatic medication in knee osteoarthritis.” Dr Herrero-Beaumont of the Fundacíón Jiménez Díaz in Madrid, found glucosamine sulfate to be more effective than the over-the-counter painkiller acetaminophen for joint discomfort.
• The study was done at multiple hospitals, was randomized to prevent bias, tested against both placebo and real medications and no-one (including the doctors) was aware of who was getting the placebo or the Glucosamine.
• The Glucosamine Unum in Die Efficacy (GUIDE) trial took place in 13 different European hospitals and compared a 1,500mg daily dose of glucosamine sulfate and a much larger 3,000 mg dose of the OTC drug Acetaminophen (commonly found in Tylenol, Excedrin, and many others) to a placebo in 318 patients.

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Additional commentary and what this means to you.

It has taken over five years for the official results of these well designed studies to finally scientifically prove the effectiveness of Glucosamine Sulfate and Chondroitin Sulfate.

Now that glucosamine and chondroitin in combination have been shown to work at least as well as Celebrex or NSAIDS, with a far better safety profile, the question remains...

What is your best glucosamine and chondroitin option?

We have researched this question and have presented our findings and recommendations within the Natural Remedies section.

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